Biotechnology has tremendous applications in the areas of agriculture, environment, fuels and chemicals, food and drink, gene cloning, and medicine. Also, when biotechnology applies to humans especially in genetic engineering, it stimulates controversial debates on bioethical issues. While biotechnology is increasing in the news, awareness of its overall significance remains limited. This is especially true for high school students. Many western governments have been planning to bridge the gap. In Hong Kong however, the pace is comparatively slow. This study is unique in being the first in Hong Kong to inquire into the student perception (knowledge and attitudes) of biotechnology. Based on the findings, this study is to make recommendations for integrating biotechnology in the science classes.[Copyright © 1999 Association for the Advancement of Computing in Education (AACE).]