This article looks historically at the 'Regionalisation' of higher education in the United States and East Asia. First, it recounts the proliferation of regional networks in American higher education in the 1950s and 1960s, with a focus on the international dimensions of these networks. Then, it revisits a major conference on 'University Cooperation and Asian Development', hosted by the University of Hong Kong in 1966. Noting that domestic university collaborations often paved the way for subsequent international networks, the article situates both American and Asian networks in their broader geopolitical context to show the relationship between higher education, regional development and the pursuit of soft power.[Copyright of Journal of Higher Education Policy and Management is the property of Routledge. Full article may be available at the publisher's website: http://dx.doi.org/10.1080/1360080X.2013.786858]