Purpose: This paper aims at review the rationale of STEM education in business subjects prospective. STEM (Science, Technology, Engineering and Mathematics) education is a new trend in the Asia-Pacific region in the recent years, such as Singapore and Japan. Through studying others countries experience, it discuss the missing link of STEM education in Hong Kong. Methodology: First of all, it describes the purpose of STEM education and recent development in Hong Kong secondary school by reviewing HKSAR STEM education report. Second, there are two STEM education sample schools from western country and Singapore. It discusses the purpose of promoting entrepreneurial STEM education in these countries. Finally, compare with others countries, it try to identify the missing link between business education and STEM education by reviewing Hong Kong's entrepreneurial education. Result: Although entrepreneurial education is mature and supported by professional parties in Hong Kong, there is a gap for business subjects to enhance the effectiveness of STEM education by integrating entrepreneurial education into STEM education, especially in secondary level. Conclusion and discussion: It is necessary to provide authentic learning for students from private and public sector commitment. Cross subject collaboration for professional development should also developed at secondary school. It aims at not only accommodating the purpose of Hong Kong STEM education, but also enhance teachers' collaboration and students' cross subject integration competence in problem solving with various stakeholders' support.