The present research was designed to examine the psychometric properties of a Chinese version of the MLQ using a construct validation approach in 1,089 Hong Kong secondary school students. Confirmatory factor analyses were used to examine the structural validity of MLQ. Correlational analyses were done to assess how meaning in life dimensions relate to life satisfaction, self-reported duration of daily sleep, and connectedness to social agents. Confirmatory factor analysis showed that the modified two-factor model of meaning in life with presence of meaning and search for meaning as key dimensions, was valid and reliable in the current sample. Evidence for configural, metric, and scalar invariance was found across boys and girls. Meaning in life dimensions was differentially associated with connectedness to various social agents, life satisfaction, and average daily sleep. MLQ is a psychometrically valid tool to measure meaning in life among Hong Kong Chinese students. Copyright © 2021 Informa UK Limited, trading as Taylor & Francis Group.