Innovative and entrepreneurial talents are central to building an international innovation technology hub in the Guangdong-Hong Kong-Macao Greater Bay Area and higher education plays the main role in cultivating such talents. In a random sampling, a total of 5,021 valid questionnaires were obtained from 58 colleges and universities in the Guangdong-Hong Kong-Macao Greater Bay Area, including the "9 + 2" cities. The results show that the total satisfaction score of students' evaluation of innovation and entrepreneurship education in colleges and universities was 3.43, which is in the upper-middle level. Specifically, the implementation and popularization of innovation and entrepreneurship education in colleges and universities is satisfactory, and the corresponding curriculum system can be adjusted in accordance with the strategic development trends of the Greater Bay Area. However, there are some problems to be solved. First, it is still difficult to integrate effectively the regional innovative and entrepreneurial resources in the process of innovation and entrepreneurship education. Second, innovation and entrepreneurship education emphasizes theory using a single teaching method, and there is insufficient integration with professional education. In addition, there is a shortage of innovation and entrepreneurship platforms for practice, and the cooperation mechanisms between colleges and universities, society, and government need to be improved. Last, there is a serious shortage of teachers. In order to promote the development of innovation and entrepreneurship education, colleges and universities must establish a hierarchical system based on their own conditions, taking advantage of the innovative and entrepreneurial resources and industrial characteristics of the core cities in the Guangdong-Hong Kong-Macao Greater Bay Area. Moreover, it's necessary to develop excellent courses integrating professional education with innovation and entrepreneurship education, and