Using both quantitative and qualitative methods, this study aims to examine the relationship between the personal, communal, environmental, and transcendental domains of spiritual well-being of university students in Hong Kong and their academic performance measured by Cumulative Grade Point Average (CGPA). The study is guided by two research questions. Research Question One: What are the relationships between university students’ spiritual well-being and their academic performance as measured by CGPA?Research Question Two: If there are any relationships between university students’ spiritual well-being and their academic performance, how are the background demographic variables, including major discipline, family socio-economic status and religious beliefs related to spiritual well-being and academic performance?The quantitative part of the study consists of a survey that collects data from a random sample of 1,130 Year 2 and Year 3 students from three universities in Hong Kong. The questionnaire used is adapted from the Spiritual Health And Life-Orientation Measure (SHALOM) developed by John Fisher. The quantitative findings indicate a moderate positive relationship between the spiritual well-being of the respondents and their academic performance; the results also demonstrate that students’ academic performance corresponds with their levels of spiritual well-being. The qualitative part of the study is comprised of 11 focus group discussions. The findings of this support the quantitative findings and contribute to the exploration of the background variables that mediate the abovementioned positive relationship. The study also involves data triangulation.The findings suggest that the resulting positive relationship can be explained by three demographic features, namely, family social-economic status, major disciplines, and religious beliefs. Thus, these demographic features are used to delineate and analyze the positive relationship and the various patterns of the relationship