The purpose of this study is to examine students’ creative thinking skills in STEAM-based activities by using the Makey Makey invention kit in designing the human-centred design instruments (HCDIs). Human-centred design is a process of designing for people (IDEO, 2011). This research aims to investigate the application of students’ creative thinking skills in developing solution to problem in human perspectives in everyday life through designing the human-centred designed instruments with the combination of creative exchange of knowledge and personal experiences between the designers (students) and users in different age group.Data were collected from 264 adolescent females (n = 264) in the age between 11 and 13, who had participated in the STEAM-based activities in a Hong Kong local secondary school. The STEAM project was provided through the school curriculum to examine the students’ level of creative thinking across disciplines in designing the human-centred design instruments (HCDIs) with Makey Makey to match the actual needs of different age groups, including children (aged 3-6), adults and elderly (aged over 65). The research objectives are concerned with the students’ involvement and attitude in participating the STEAM-based activities as well as their application of their creative thinking skills in the real-world context. The students’ experiences of thinking creatively were investigated through the five stages of creative thinking under the framework of “Creative Learning Spiral” by Mitch Resnick (2007) in STEAM-based activities in Hong Kong context.Pre- and post-treatment attitudinal questionnaires, two class observations and four interviews with both teachers and students were conducted to examine the change of students’ attitude towards creative thinking. Data findings revealed that 1) a slight increase in the students’ level of attitude change towards creative thinking through designing the human-centred design instruments (HCDIs) with the invention kit