This thesis explores multiple relationships among school missions, developmental programs, and the spiritual well-being of students and teachers at 5 Hong Kong secondary schools in which only 3 schools namely an Anglican school (School A), a nonreligious school (School B), and a Catholic school (School E) were selected for further case study according to their quantitative results and school management approval.A mixed methods approach was applied to examine these relationships. A quantitative instrument, the Spiritual Health and Life Orientation Measure, was adopted to assess the spiritual well-being of 2,125 students and 96 teachers. Statistical results revealed that students from School E showed the most highest level of spiritual well-being, followed by School A and then School B, with significant differences observed among the three schools. Teachers’ spiritual well-being were also ranked in the same order of School E, School A and School B but the differences were not significant.A qualitative investigation involved a textual analysis of school documents including the guidelines of school sponsoring bodies and the schools’ mission statements (first-order documents), as well as their school development plans and annual plans (second-order documents). Individual interviews with principals and teachers (n = 21), focus group interviews with senior students (n = 31), and school visits for ethos observations were conducted to identify daily practices and real interactions indicating the influence of developmental programs, teachers’ values, and the schools’ mission statements on the nurturing of the students’ spiritual well-being.The content of developmental programs was found to be closely related to the content of the schools’ mission statements and the values of the schools’ sponsoring bodies. Positive relationships were observed between the number of developmental programs at the schools and the students’ level of spiritual well-being. For all 3 schools, both the