Recent educational research reveals that case studies can be applied in STEM education as a pedagogically powerful method for teaching scientific concepts and contents as well as science process skills. However, there exists very little research or literature on the instructional use of case study in STEM education in Hong Kong. Hence, a team of science educators and scientists initiated a collaborative project to investigate how feasible case study can be incorporated in STEM education. Over a period of seven months, we developed case teaching materials (including case story line with authentic data, worksheets for field trip and laboratory experiments, online/remote-controlled experiments, aerial movies filmed by drones and virtual reality videos etc.) for topics purposefully selected from (i) Hong Kong Wetland Park, (ii) two large sewage treatment plants/projects of the Drainage Services Department, and (iii) landfill gas used by the Town Gas company. This teaching approach was implemented in three different courses in our education university. A set of instrument for mixed research method was specifically developed or modified for collecting data on the learning effectiveness and feedback from a total of 115 students enrolled in the aforementioned three courses. Essential features of the case teaching materials and preliminary findings of the evaluation will be presented. The discussion on the difficulties encountered in the development and implementation stages as well as the direction for the future research and development work will be highlighted.