Many Hong Kong students find learning organic chemistry hard as the subject requires them to master complex knowledge and higher order thinking skills. This paper reports a case study of adopting ChemSense, a computer-supported collaborative learning package for learning and teaching of chemistry, to support the learning of organic chemistry for a group of matriculation level students in Hong Kong. Data regarding the students' views of the usefulness of collaborative learning and ChemSense were collected and analyzed. Although there is no statistical evidence to conclude that students who worked collaboratively can improve their individuals' knowledge of the subject matters better than those who did not, evidence of knowledge construction was identified when examining the content of students' discussions. The students in the experimental group also showed improvement in learning attitude and were positive towards the adoption of collaborative learning in studying organic chemistry.