Teaching has become increasingly challenging as a result of high expectations and demands placed on education systems. With an overview of the pathways to become a teacher and the teacher policy context in Hong Kong, this chapter presents the case of an undergraduate ITE programme offered by the Education University of Hong Kong. The ITE programme aims at preparing high quality ITE graduates with the key attributes of Professional Excellence, Ethical Responsibility and Innovation. The heightened expectations and demands placed on teachers in Hong Kong have been exacerbated by the enormous difficulties at the societal level since 2019. The outbreak of the COVID-pandemic and the major socio-political issues have generated unprecedented uncertainties in society at large and the education community. The chapter examines how these extraordinary circumstances place novel demands on teachers’ professional competence, and hence requiring new professional knowledge. The creation of hybrid spaces in ITE and communicative safe spaces is needed to foster the co-construction of new professional knowledge. The chapter ends by arguing that professional competence coupled with teacher buoyancy can likely enhance the potential for ITE graduates to stand tall against immense everyday challenges of beginning teaching in an era of unprecedented uncertainties. Copyright © 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.